Pain Control During ESWL Using Non-Opioid Analgesics

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-75
SponsorUniversity of Gaziantep

About this trial

This prospective randomized controlled trial aims to compare the analgesic efficacy of three non-opioid analgesics (ibuprofen, paracetamol, and tenoxicam) during extracorporeal shock wave lithotripsy (ESWL). All patients undergoing ESWL will be randomly assigned into four groups including a placebo group.

Pain intensity will be assessed using the Visual Analog Scale (VAS) at the 5th, 10th, 15th, and 20th minutes during the procedure. In addition to comparing analgesic efficacy, the study will evaluate patient-related and stone-related factors affecting pain perception, including body mass index, subcutaneous fat thickness, and stone density measured by Hounsfield Units.

The study also aims to assess the relationship between analgesic efficacy, energy levels applied during ESWL, and treatment outcomes such as stone-free rates. The findings may contribute to optimizing individualized pain management strategies and improving treatment efficiency in ESWL procedures.

Eligibility criteria

Qualifiers

Adult patients (≥18 years) undergoing ESWL for urinary stone disease

Patients with kidney or ureteral stones indicated for ESWL

Ability to provide informed consent

Disqualifiers

Known hypersensitivity or contraindication to ibuprofen, paracetamol, or tenoxicam

Chronic pain conditions or regular use of analgesics

Pregnancy or breastfeeding

Severe renal or hepatic impairment

Trial design

Treatments tested in this trial

  • Ibuprofen (Brufen®)
  • Paracetamol (drug)
  • Tenoxicam
  • Placebo

Treatment groups

160 Participants
are divided into 4 treatment groups

Sponsors and collaborators