Paracetamol and Mannitol Injection and Postoperative Delirium
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age60+
SponsorXiangya Hospital of Central South University
About this trial
The aim of this multi-center RCT is to investigate the effect of intravenous acetaminophen (paracetamol and mannitol injection) on postoperative delirium, comparing with intravenous sufentanil, in elderly noncardiac surgical patients admitted to ICU.
Eligibility criteria
Qualifiers
Age ≥ 60 years;
Admitted to ICU after a noncardiac surgical procedure
Moderate to severe acute pain, with a postoperative pain score ≥ 5 based on the 11-point Numerical Pain Rating Scale (NPRS)
Signed informed consent form
Disqualifiers
Preoperative medical history: schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis
History of psychiatric disease or significant neurocognitive disorder such as dementia or retardation, making POD assessment impossible
Language or communication barrier making POD assessment impossible
Intracranial surgery
Trial design
Treatments tested in this trial
- Acetaminophen group
- Sufentanil group
Treatment groups
1,092 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov