Partial Oral Antibiotic Treatment for Bacterial Brain Abscess
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorHenrik Nielsen
About this trial
The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients will continue with this treatment for another 4 weeks or longer while the other half will be assigned to oral antibiotics for the remaining duration of treatment.
Eligibility criteria
Qualifiers
A clinical presentation (e.g. headache, neurological deficit or fever) and cranial imaging (CT or MRI) consistent with brain abscess AND
The physician responsible for the patient decides to treat the patient for bacterial brain abscess AND
Ability to take and absorb oral medications (including by nasogastric tube) AND
To have received relevant antibiotic therapy for bacterial brain abscess for 14 consecutive days before randomisation AND
Disqualifiers
Expected substantially reduced compliance with treatment (e.g. IV drug abuse)
Pregnancy (proven by positive urine or plasma human chorionic gonadotropin test in fertile women <50 years of age)
Concomitant (empirical) brain abscess treatment for tuberculosis, nocardiosis, Pseudomonas spp., fungi, toxoplasmosis or other CNS parasites
Device related brain abscesses (e.g. deep brain stimulators, ventriculo-peritoneal shunts)
Trial design
Treatments tested in this trial
- Early transition to oral antibiotics
- Standard treatment of intravenous antibiotics
Treatment groups
400 Participants
are divided into 2 treatment groupsSponsors and collaborators
Henrik Nielsen
Lead sponsor
Aalborg University Hospital
Sponsor institution
Source ClinicalTrials.gov