This study is a prospective, randomized, double-blinded, placebo-controlled study of the drug colchicine in the acute postoperative period for patients who are undergoing a total knee arthroplasty (TKA). Patients aged 18 years or older who are undergoing TKA will be invited to participate in the study. The primary endpoint of this study is to determine if colchicine, an anti-inflammatory medication commonly used for gout attacks, will decrease the postoperative pain of patients undergoing elective TKA.
Patients 18 years or older undergoing elective total knee arthroplasty for osteoarthritis.
Subject has impaired hepatic function (Child-Pugh Class >B)
Subject has impaired renal function (GFR < 60 ml/min/1.73 m2)
Subject has known adverse reaction to colchicine
Subject has chronic opioid use (Filled opioid medication twice within 6 months of surgical date)
Geisinger Clinic
Lead sponsor
St. Luke's Hospital, Kansas City, Missouri
Collaborator