Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorMarquette University

About this trial

The goal of this randomized clinical trial is to compare patient-reported pain and oral health-related quality of life during the first postoperative week following extraction and bone graft surgery in patients who received preemptive ibuprofen versus placebo. Participants will receive ibuprofen 600mg or placebo by mouth with water 1 hour prior to extraction and bone graft surgery.

The primary question it aims to answer is:

• Does preemptive ibuprofen have an effect on postoperative pain 1 hour following extraction and bone graft surgery compared to placebo?

Secondary questions are:

* Does preemptive ibuprofen have an effect on pain during the first 3 postoperative hours and 7 postoperative days following extraction and bone graft surgery compared to placebo? * Does preemptive ibuprofen have an effect on oral health-related quality of life during the 7 postoperative days following extraction and bone graft surgery compared to placebo?

Eligibility criteria

Qualifiers

Age >18 years

Good general health (controlled conditions)

Fluent in English

Treatment-planned for single site extraction and bone graft surgery

Disqualifiers

Pregnancy

Site with active infection i.e purulence, abscess formation

Patients experiencing pain pre-operatively

Oral surgery in more than one site/quadrant in the same session

Trial design

Treatments tested in this trial

  • Ibuprofen 600 mg
  • Placebo
  • Acetaminophen

Treatment groups

50 Participants
are divided into 2 treatment groups

Sponsors and collaborators