Health Trials

Preoperative Indomethacin and Paracetamol for Pain Management During Oocyte Retrieval in IVF Patients

ConditionsPainOocyte Retrieval
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorWestern Galilee Hospital-Nahariya

About this trial

This is a randomized controlled trial evaluating the efficacy of preoperative analgesic medications - Indomethacin (100 mg per rectum) and Paracetamol/Acamol (1,000 mg intravenously) - for pain management during oocyte retrieval in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

Eligibility criteria

Qualifiers

Women undergoing oocyte retrieval for IVF or ICSI

Age 18-45 years

ASA physical status classification I or II

Willing and able to provide written informed consent

Disqualifiers

Known allergy or hypersensitivity to Indomethacin, any NSAID, or Paracetamol

History of gastrointestinal bleeding or peptic ulceration

Renal impairment (GFR < 30 ml/min/1.73m² or Creatinine > 1.04 mg/dL)

Hepatic impairment (ALT > 55 U/L, AST > upper limit of normal, ALP > upper limit of normal, Total Bilirubin > 1.2 mg/dL, or Albumin < 3.5 g/dL)

Trial design

Treatments tested in this trial

  • Indomethacin 100Mg Suppository
  • Paracetamol / Acetaminophen

Treatment groups

177 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Western Galilee Hospital-Nahariya

Lead sponsor

Source ClinicalTrials.gov