Prevention and Treatment of Frostbite Infection With Antimicrobial Pharmacokinetic Analysis
ConditionFrostbite
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-99
SponsorUniversity of Colorado, Denver
About this trial
This study will compare the effectiveness of two different treatments for preventing infection from frostbite injuries. These two treatments are A) aloe vera and B) long-acting silver wound dressings. The investigators will also study the safety and effectiveness of Dalbavancin, an FDA approved antibiotic used for treating people who develop frostbite wound infections, as well as evaluate how frostbite damage to individuals' bodies may affect how fast their kidney clear drugs from their systems.
Eligibility criteria
Qualifiers
All aims, aged ≥18 - < 99 years old admitted to UCH Burn Center with frostbite injury
Aim 1: Admitted to UCH Burn Center with acute (within 4 days of cold exposure) frostbite injury
Aim 2: Admitted to UCH Burn center with a clinically confirmed or suspected infected frostbite wound
Disqualifiers
Pregnant patients
Prisoners
Anticipated death within 48 hours of admission
Inability to obtain consent from patient, legally authorized representative, or proxy
Trial design
Treatments tested in this trial
- Long-Acting silver dressings
- Aloe Vera
- Dalbavancin
Treatment groups
100 Participants
are divided into 3 treatment groupsSponsors and collaborators
University of Colorado, Denver
Lead sponsor
Congressionally Directed Medical Research Programs
Collaborator
Source ClinicalTrials.gov