PRevention Of Trauma-related Infections Through an Embedded Clinical Trials Network

ConditionSurgical Site Infection

Trial statusNot yet recruiting

Trial phasePhase 4

Trial typeInterventional

Biological sexAll

Age18+

SponsorThe University of Texas Health Science Center, Houston

About this trial

The purpose of this study is to compare the effectiveness of 2 prophylactic antibiotic regimens, ertapenem and cefazolin with metronidazole, in preventing organ space surgical site infections (OS-SSI) after emergency trauma laparotomy embedded into routine clinical care and to validate a Bayesian OS-SSI risk calculator using Trauma Quality Improvement Program (TQIP) standardized variables

Eligibility criteria

Qualifiers

Trauma laparotomy within 90 minutes of arrival

Disqualifiers

Patients with a known allergy to cephalosporins or β-lactamase inhibitors

Prisoners

Pregnant and lactating women

Trial design

Treatments tested in this trial

Ertapenem
Cefazolin and Metronidazole.

Treatment groups

300 Participants

are divided into 2 treatment groups

Sponsors and collaborators

The University of Texas Health Science Center, Houston

Lead sponsor

Surgical Infection Society

Collaborator

Source ClinicalTrials.gov