Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-80
SponsorThe University of Texas Medical Branch, Galveston

About this trial

The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease. The main question it aims to answer is

"The use of Cisatracurium with neostigmine leads to less post-operative pulmonary complications than Rocuronium with sugammadex."

Eligibility criteria

Qualifiers

The subject is able and willing to provide and sign informed consent

The subject must be between 18 and 80 years of age

The subject should have chronic kidney disease as defined by glomerular filtration rate

The surgery must require general anesthesia with endotracheal intubation and neuromuscular blockade

Disqualifiers

Any patient under the age of 18

Any patient over the age of 80

Any patient with end stage renal disease

Any patient requiring dialysis

Trial design

Treatments tested in this trial

  • Rocuronium
  • Cisatracurium
  • Sugammadex
  • Neostigmine

Treatment groups

490 Participants
are divided into 2 treatment groups