Concurrent vaccination scheduling for key target populations in Rwanda, such as healthcare workers, may confer significant advantages in the provision of vaccine coverage to several infectious diseases. This is a phase IV vaccine trial that looks to establish if two licenced vaccines, the rVSVΔG-ZEBOV-GP vaccine for protection against Ebola virus and messenger ribonucleic acid (mRNA) COVID vaccine for protection against SARS-CoV-2 virus, given concurrently to self selected healthy adult volunteers confers an acceptable safety profile and immunogenicity response.
Healthy male and female adults between ages 18-50 years, who are able and willing to provide written informed consent and will comply with the study requirements.
Already completed a primary course of COVID-19 immunisation (any World Health Organisation approved primary immunisation course is acceptable).
Unwilling or unable to provide written informed consent to take part
Unwilling or unable to comply with study procedures
Previously received an Ebola vaccine or previous exposure to Ebola virus (including serological and clinical diagnoses, irrespective of viral strain)
Not received a primary course of COVID-19 immunisation
University of Birmingham
Lead sponsor
Project San Francisco
Collaborator
Rwanda Biomedical Centre
Collaborator
Merck Sharp & Dohme LLC
Collaborator