This study will compare a short-term course (12 week) glucocorticoid regimen with the Conventional 24-week regimen as originally proposed by KDIGO. The purpose of the study is to determine a short-term course (12 week) of glucocorticoid decreases the time to first relapse in adults presenting with steroid sensitive nephrotic syndrome.
Urine protein: creatinine ratio ≥3000mg/g (300mg/mmol)
Serum/plasma albumin level < 30g/L
Age ≥ 16 years at the time of diagnosis
No prior therapy with steroids, immunosuppressive or cytotoxic agents for any form of renal disease (other than the 28 days of prednisolone therapy given initially as routine clinical practice)
Secondary nephrotic syndrome
Contradictions for glucocorticoids
SRNS: Lack of complete remission within 4 weeks of therapy with daily prednisone or prednisolone at standard dose
anti-PLA2R positive