Single Shot Exparel vs Catheters in Lower Extremity Trauma

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorGeorge Washington University

About this trial

This study will compare the use of single-shot Exparel, a long-acting local anesthestic, with the use of catheters that deliver a continuous flow of the short-acting local anesthetic ropivacaine. The comparison will be done in patients who receive preoperative adductor and sciatic nerve blocks prior to orthopedic surgery for traumatic lower extremity injury. The patients' pain will then be monitored for up to 72 hours after injection, measuring every 12 hours after injection until the 72-hour mark. Opioid consumption (measured in morphine milligram equivalents) will also be tracked over this time period.

Eligibility criteria

Qualifiers

Closed lower extremity orthopedic injury

Opioid naive patients

No other significant surgical injuries on admission as determined by study physician

Disqualifiers

Allergy to local anesthetics

Multiple traumatic injuries

Weight less than 60 kg

Prior opioid use or risk of increased pain control needs as determined by PI

Trial design

Treatments tested in this trial

  • Bupivacaine
  • Exparel + Bupivacaine

Treatment groups

90 Participants
are divided into 2 treatment groups

Sponsors and collaborators