Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
ConditionMonkeypox
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age2+
SponsorMcMaster University
About this trial
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
Eligibility criteria
Qualifiers
Household member of person with laboratory confirmed mpox
Age ≥ 2 years
Within 14 days of onset of illness in mpox index case
Disqualifiers
Pregnancy
Breastfeeding
Past serious allergic reaction to study vaccine components
Previous smallpox vaccination
Trial design
Treatments tested in this trial
- Bavarian Nordic smallpox vaccine
- Typhoid VI Polysaccharide Vaccine Injectable Solution
Treatment groups
3,000 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov