Sore Throat After Open Neck Elective Surgery
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorSaint Petersburg State University, Russia
About this trial
This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough following thyroid or parathyroid surgery with neuromonitoring.
A total of 764 adult patients undergoing elective neck surgery at Saint-Petersburg State University Hospital will be enrolled and randomly assigned to receive either a hydrocortisone-coated or lidocaine-coated endotracheal tube.
Outcomes will be assessed upon awakening from anesthesia, at 24 hours, and again at 3 days postoperatively.
The findings may contribute to improving postoperative comfort and recovery for patients undergoing similar surgical procedures.
Eligibility criteria
Qualifiers
Patients scheduled for elective open surgery on the thyroid/parathyroid glands with intraoperative neuromonitoring.
Age ≥18 years.
Willing and able to provide voluntary informed consent for participation in the study.
Disqualifiers
Pregnancy (for women of childbearing potential).
Known allergy to hydrocortisone or lidocaine.
Refusal to participate in the study.
Trial design
Treatments tested in this trial
- Hydrocortisone Acetate 1% Ointment
- Lidocaine hydrochloride 0,05% with chlorhexidine
Treatment groups
764 Participants
are divided into 2 treatment groupsSponsors and collaborators
Saint Petersburg State University, Russia
Lead sponsor
Smooth Drug Development
Collaborator
Source ClinicalTrials.gov