Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age40+
SponsorCentral Denmark Region
About this trial
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.
Eligibility criteria
Qualifiers
Patients over the age of 40
EMT or Paramedic suspected AECOPD
Confirmed suspicion of COPD
Disqualifiers
Bronchospasm due to asthma, allergic reaction or non-COPD conditions
Known or suspected pregnancy
Prehospital Non-invasive, invasive or assisted bag mask ventilation
Allergy to inhaled bronchodilators (Salbutamol)
Trial design
Treatments tested in this trial
- Titrated Oxygen
- Standard Oxygen
Treatment groups
1,888 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov