Steroid Use in Treatment of Allergic Reactions to Food

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age6-18
SponsorJohannes Trueck

About this trial

In this study, the investigators want to find out whether a specific medication commonly used for severe allergic reactions is really necessary. When children have allergic reactions to foods, they are often given medications to relieve the symptoms. In addition to adrenaline and antihistamines, steroids are frequently administered in German-speaking Switzerland. However, it is unclear whether steroids are really helpful in this situation. To investigate this, the investigators are comparing two groups: one group receives additional steroids, and the other does not. Which treatment a participant receives is decided randomly, like flipping a coin. The study takes place during a pre-scheduled provocation test at the clinic. If an allergic reaction occurs, the usual emergency medications will be administered. Doctors will closely monitor how the reaction develops. No additional tests or visits are required. The results of this study could help improve allergy treatment in the future.

Eligibility criteria

Qualifiers

suspected or confirmed IgE-mediated food allergy

Disqualifiers

Non-IgE mediated food allergies

Non-food allergies

Age outside the specified range

Contraindications for an oral food challenge or oral steroid use within one week before the challenge.

Trial design

Treatments tested in this trial

  • Antihistamines
  • Systemic corticosteroids
  • Adrenaline (rescue medication)

Treatment groups

160 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Johannes Trueck

Lead sponsor

University Children's Hospital, Zurich

Sponsor institution

University Children's Hospital Basel

Collaborator