The primary objective is to compare physician-assessed clearance of telangiectatic veins between treatment legs using the Physician Global Aesthetic Improvement Scale (PGAIS). Secondary objectives include assessment of procedural pain, safety outcomes, and patient satisfaction.
Subjects aged 20-75years.
Fitzpatrick skin types I-VI.
Presence of lower extremity telangiectatic veins (<1 mm) suitable for sclerotherapy (reticular veins ≥1 mm can be present but are not required).
Duplex ultrasonography negative for saphenous vein reflux in both legs.
Positive duplex ultrasonography demonstrating saphenous vein reflux.
Prior sclerotherapy or vascular laser treatment to the lower extremities within the past 6 months prior to screening/baseline
History of ulceration, thrombophlebitis, or deep vein thrombosis (DVT) in the lower extremities.
Active infection, open wounds, or inflammatory dermatoses (e.g., eczema, psoriasis, dermatitis) in the treatment area.