Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy
ConditionLumbar Disc Herniation
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Missouri-Columbia
About this trial
The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.
Eligibility criteria
Qualifiers
Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation
Failed conservative treatment - rest, anti-inflammatory medications, physical therapy
Radiculopathy present - positive tension signs or sensory/motor neurologic deficits present
Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation
Disqualifiers
Concomitant spinal stenosis, segmental instability, or spondylolisthesis
Previous surgery at the affected level or recurrent herniation
Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression
Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment
Trial design
Treatments tested in this trial
- Dexamethasone
- saline 0.9%
Treatment groups
200 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov