The primary objective is to evaluate the impact of oliceridine versus sufentanil for perioperative analgesia on the incidence of chronic postsurgical pain (CPSP) in patients undergoing video-assisted thoracoscopic surgery.
① Age 18-75 years, ASA physical status I-III, BMI 18-30 kg/m²;
Scheduled for unilateral video-assisted thoracoscopic surgery (VATS) lung resection, including wedge resection, segmentectomy, lobectomy, or radical resection for lung cancer;
Preoperative pain score <1 on the Numeric Rating Scale (NRS);
Ability to understand the study objectives and procedures, with voluntary informed consent obtained;
① History of chronic pain or long-term analgesic use prior to surgery;
Previous ipsilateral thoracic surgery;
Prior neoadjuvant radiotherapy or chemotherapy;
Severe cardiovascular or cerebrovascular disease, or hepatic/renal dysfunction (ALT/AST >3× upper limit of normal; eGFR <60 mL/min/1.73m²);
Parallel
Oliceridine
Drugpostoperative patient-controlled analgesia (PCA)
Sufentanil
DrugSufentanil
Incidence of chronic pain after surgery
Chronic pain intensity was assessed by a numeric rating scale (NRS) using a telephone questionnaire
postoperative acute pain NRS scoring
Acute pain NRS score (rest versus cough) at 24 and 48 hours after surgery
Incidence of adverse events
Chronic pain NRS score 3 months after surgery
assessed by NRS scale
Neuropathic pain (DN4 score ≥ 4)
the DN4 questionnaire is a brief and user-friendly screening tool designed to identify the presence of neuropathic pain components
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