The Effects of Different Anesthetics on the Brain's Neural Networks

Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-65
SponsorFudan University

About this trial

This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively. It intends to explore the macro neural mechanisms underlying anesthetic unresponsiveness, so as to further elucidate the mechanisms by which anesthetics induce loss and recovery of consciousness. In addition, this study will identify neural biomarkers under general anesthesia for monitoring patients' actual intraoperative consciousness status. The findings will facilitate the development of monitoring indicators and devices reflecting intraoperative consciousness during general anesthesia, enabling more accurate assessment of patients' intraoperative consciousness status.

Eligibility criteria

Qualifiers

Patients scheduled for elective non-cardiac surgery;

American Society of Anesthesiologists (ASA) physical status classification I-II;

Aged 18 to 65 years, regardless of gender;

Body mass index (BMI) greater than 18 kg/m² and no more than 31 kg/m²;

Disqualifiers

Presence of severe cardiovascular diseases or hepatic and renal insufficiency;

Hearing impairment;

History of psychiatric disorders or communication disorders;

Anticipated difficult airway;

Trial design

Treatments tested in this trial

  • propofol
  • Dexmeditomidine
  • Esketamine

Treatment groups

120 Participants
are divided into 3 treatment groups

Sponsors and collaborators