The Impact of Dietary Salt on the Severity of Eczema
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, San Francisco
About this trial
The goal of this clinical trial is to evaluate the feasibility of low-sodium diet to improve eczema severity. The main questions it aims to answer are:
* Does a low-sodium diet improve eczema severity? * How does a low-sodium diet impact skin sodium concentration? * Is skin sodium concentration associated with eczema severity?
Researchers will ask all participant to follow a low-sodium diet, then compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake.
Participants will:
* Follow a low-salt diet for the duration of the 24-week study * Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa * Complete up to 4 virtual check-in visits * Visit the clinic 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI
Eligibility criteria
Qualifiers
Participants ages 18 years
Willing and able to undergo non-contrast MRI.
Disqualifiers
Contraindications to MRI (such as cardiac pacemakers, claustrophobia, non-compatible intracranial vascular clips, IUDs, or other implants)
A cardiac event in the past 6 months
Impaired function of the liver or kidney (glomerular filtration rate <60 mL/min)
Medications that influence sodium excretion (e.g., diuretics or SGLT2 inhibitors)
Trial design
Treatments tested in this trial
- Sodium chloride tablets
- Placebo Tablets
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of California, San Francisco
Lead sponsor
United States Department of Defense
Collaborator
Source ClinicalTrials.gov