This study will conduct a single-center clinical trial to explore the initial therapeutic effect of ginkgo biloba dropping pills, huperzine A injection and median nerve electrical stimulation in patients with cognitive impairment.
Be over 18 years old
Residual cognitive impairment due to brain injury
No previous history of brain-related diseases except this one
The patient had severe underlying disease and unstable vital signs
The patient was complicated with consciousness disorder and could not cooperate with cognitive function assessment ③ Allergic to drugs or contraindications in drug use ④ There are contraindications of median nerve electrical stimulation
Parallel
Median nerve electrical stimulation treatment
Other interventionMedian nerve electrical stimulation is an electrical stimulation therapy in which the electrode is placed at the median nerve point 2cm above the carpal wrinkles on the palmar surface of the wrist joint. Generally, the right median nerve is used for electrical stimulation. Electrical stimulation improves cognitive function by stimulating neurons in the brain and improving information transmission between neurons. When electrical current stimulates the brain, it can increase the activity level of neurons and promote the signal transmission between neurons. Its mechanism of action includes the regulation of neurotransmitter acetylcholine, thereby enhancing cognitive function.
Huperzine A injection
Drugintramuscular
Ginkgo leaf dropping pill
Drugoral
to assess the MMSE score
to assess the MoCA score
to assess the ADAS-cog score
to assess the HAMD score
to assess the HAMA score
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Wanbangde Pharmaceutical Group Co., LTD
Lead sponsor
Ganzhou City People's Hospital
Collaborator
