Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Health Network, Toronto

About this trial

The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).

Eligibility criteria

Qualifiers

Patients undergoing open reduction internal fixation (Volar approach) for operative management of a distal radius fracture;

Aged 18 or older;

Provision of informed consent;

Cognitive ability and English-language skills required to complete outcome measures.

Disqualifiers

Revision surgery or any additional operative management of ipsilateral wrist injury

Distal radius fracture treated with a dorsal approach

Known history of lymphedema or lymph node dissection in the operative extremity

Known chronic pain conditions, fibromyalgia, or polymyalgia rheumatic

Trial design

Treatments tested in this trial

  • Topical TRanexamic Acid
  • Placebo

Treatment groups

90 Participants
are divided into 2 treatment groups