Treatment of Seizures in Neonate With HIE
Trial statusNot yet recruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age1-30
SponsorMansoura University
About this trial
Aim of the study To evaluate and compare phenobarbital's and levetiracetam's safety and efficacy for treating seizures in neonates with moderate to severe HIE
Eligibility criteria
Qualifiers
Neonates diagnosed with moderate or severe HIE.
Presence of clinical seizures (focal / generalized tonic /colonic, myoclonic, subtle and spasms) and/or documented amplitude electroencephalogram (aEEG) abnormality within the first 72 hours.
Disqualifiers
Exclusive metabolic causes.
Serum creatinine greater than 1.6 mg/dl.
Known pyridoxine-dependent seizures.
Prior treatment with anti-epileptic drugs.
Trial design
Treatments tested in this trial
- Phenobarbital
- Levetiracetam
Treatment groups
66 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov