Study to comparing conventrional antibiotic strategies versus regimens guided by epidemiological surveillance in infected patients with cirrhosis.
Cirrhotic patients with acute decompensation aged ≥18 years.
Proven or suspected bacterial infection requiring antibiotic therapy (diagnosis will be established according to local guidelines, Appendix 1).
Signed informed consent or consent given by their legal representatives or close relatives.
Bacterial infection lasting for > 48 hours.
Infection in a critically ill cirrhotic patient (ICU admission). In this population, epidemiological surveillance is standard clinical practice.
Evidence of current locally advanced or metastatic malignancy (patients with hepatocellular carcinoma within the Milan criteria and non-melanocytic skin cancer can be included).
Pregnant and/or breast-feeding woman.
Eva Bonfill
Lead sponsor
Institut d'Investigacions Biomèdiques August Pi i Sunyer
Sponsor institution