Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorLakeland Regional Health Systems, Inc.
About this trial
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care.
The main questions it aims to answer are:
1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay?
Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice.
Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
Eligibility criteria
Qualifiers
Have a primary diagnosis of acute decompensated heart failure, and
Bilateral lower extremity pitting edema
Jugular venous distension
Hepatojugular reflex
Disqualifiers
Admission to the intensive care unit
Presence of ST-elevated myocardial infarction
Presence of type 1 non-ST elevated myocardial infarction
Dyspnea primarily due to non-cardiac cause as judged by the emergency medicine physician or admitting physician
Trial design
Treatments tested in this trial
- Furosemide intravenous solution
- Furosemide intravenous solution
- Furosemide intravenous solution
Treatment groups
600 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov