Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18-70
SponsorWeill Medical College of Cornell University

About this trial

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. One hundred subjects undergoing clinically-indicated, standard-of-care cardiac electrophysiology study (EPS) procedure for PVCs will receive adenosine and/or verapamil to learn if their arrhythmias are inducible similarly to sustained ventricular tachycardia.

Eligibility criteria

Qualifiers

Diagnosis of premature ventricular contractions (PVCs)

Scheduled to undergo an electrophysiology study with the intention of performing cardiac ablation for the treatment of PVCs

Male or female between the ages of 18 and 70 years

Capable of giving informed consent

Disqualifiers

Any structural heart disease

Coronary artery disease (≥ 70% stenosis)

Current treatment with anti-arrhythmic drugs

Pregnant

Trial design

Treatments tested in this trial

  • Adenosine

Treatment groups

100 Participants
are divided into 1 treatment group