Using a Steroid Mouthwash to Prevent Mouth Sores During Chemotherapy
ConditionOral Mucositis Due to Chemotherapy
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorWoman's
About this trial
The goal of this clinical trial is to learn if a steroid mouthwash (dexamethasone) can prevent mouth sores caused by chemotherapy in adults with cancer. The main questions it aims to answer are:
Does using dexamethasone mouthwash before and during chemotherapy lower the chance of getting moderate to severe mouth sores?
Can this approach reduce pain and improve comfort during chemotherapy?
Researchers will compare patients using the mouthwash to a historical group of patients who received similar chemotherapy but did not use the mouthwash, to see if the mouthwash helps prevent mouth sores.
Participants will:
Use a steroid mouthwash (4 times daily) for up to 8 weeks during chemotherapy
Complete a short weekly survey about mouth discomfort during infusion visits
Eligibility criteria
Qualifiers
≥18 years old
Confirmed cancer diagnosis
Scheduled to receive or receiving chemotherapy known to be associated with oral mucositis (e.g., anthracyclines and taxanes)
Ability to provide informed consent
Disqualifiers
Current tobacco usage or usage within the past 6 weeks.
HIV/AIDS
Gastrointestinal disorder (such as Crohn's disease, ulcerative colitis, or celiac disease)
History of cold sores (herpes simplex virus)
Trial design
Treatments tested in this trial
- Dexamethasone Mouthwash
Treatment groups
45 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov