Vitamin K for Perioperative Warfarin Management
ConditionAnticoagulant Therapy
Trial statusRecruiting
Trial phasePhase 4
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Michigan
About this trial
This is a feasibility study of uninterrupted warfarin with a one time dose of Vitamin K before a surgical procedure.
Eligibility criteria
Qualifiers
Warfarin therapy for ≥3 months
Use of home INR testing equipment
Scheduled for a surgical procedure that requires INR ≤ 1.5 (typically achieved with warfarin interruption)
INR ≤ 4 on day 7-10 prior to procedure
Disqualifiers
Surgical procedure does not require INR ≤1.5 (typically achieved with warfarin interruption)
Surgical procedure with a high risk of bleeding or complications (urologic procedures, bronchoscopy, epidural injections, nerve blocks, spinal surgery)
Warfarin therapy for < 3 months
Lack of English language proficiency
Trial design
Treatments tested in this trial
- Vitamin K
- Warfarin (standard without loading)
- Warfarin (standard with loading)
Treatment groups
20 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Michigan
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov