Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Health Network, Toronto
About this trial
This is a randomized, single centre, single blinded prospective study comparing the standard of care imaging guided radiation therapy and daily adaptive radiotherapy (ART) for submandibular gland-sparing in head and neck cancer
Eligibility criteria
Qualifiers
Age ≥ 18 years
Histologically proven Squamous Cell carcinoma of head and neck
Bilateral neck being treated
At least one level 1b not being treated electively and with no target structure, other than elective level II/III, <1cm to spared SMG
Disqualifiers
As judged by investigator evidence of systemic disease that makes unsuitable for study
Pregnancy
Underlying salivary dysfunction prior to treatment judged by investigator to affect likelihood of benefit from ART
Trial design
Treatments tested in this trial
- Daily adaptive radiation therapy
- Image guided radiation therapy
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov