Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorSteno Diabetes Center Greenland

About this trial

The goal of this clinical trial is to perform a detailed description of the feno- and genotype of people living with type 2 diabetes and severe obesity who are linked to care at Steno Diabetes Center Greenland.

The main questions it aims to answer are:

* Are monogenetic diabetes variants associated with the same risk of developing late diabetic complications as other types of diabetes? * Can genotyping and thereby personalized medicine be implemented in Greenland, and can personalized medicine lead to improved treatment? * What is the prevalence of sleep apnea among high-risk individuals in Greenland? * Is it possible to develop and implement a simple algorithm for the identification of sleep apnea in Greenland that can ensure treatment of severe sleep apnea?

Participants will:

* Answer WHO-5 and FOSQ-10 questionnaires regarding quality of life and functional outcomes of sleepiness * Perform VAGUS examinations for Cardiovasculare Autonomic Neuropathy * Clinical examination of height, weight, circumference of hip, waist and neck, Friedman tonsil and tongue score, nasal air flow, nasal septal deviation * Blood samples for full genome sequencing

Eligibility criteria

Qualifiers

Type 2 diabetes and/or morbid obesity (BMI >40)

Over 18 years old

Disqualifiers

Does not speak either English, Danish or Greenlandic

Trial design

Treatments tested in this trial

  • Whole genome sequencing
  • VAGUS
  • NightOwl
  • CPAP

Treatment groups

1,000 Participants
are divided into 1 treatment group

Sponsors and collaborators

Steno Diabetes Center Greenland

Lead sponsor

Zealand University Hospital

Collaborator

University of Copenhagen

Collaborator