Phenotyping Genetic Risk for Type 2 Diabetes
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age10-70
SponsorUniversity of Pennsylvania
About this trial
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Eligibility criteria
Qualifiers
Age 10-70 years
Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
Disqualifiers
prior diagnosis of type 1, type 2, or secondary diabetes
use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
acute illness that may impact insulin and glucose dynamics
pregnancy
Trial design
Treatments tested in this trial
- 75g glucose beverage (Glucola, Trutol, or similar brand)
- DXA, whole body
Treatment groups
100 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov