Phosphate Assessment in Chronic Kidney Disease Patients Study
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Texas Southwestern Medical Center
About this trial
The proposed pilot feeding study aims to explore novel pathways in phosphate metabolism and identify new biomarkers, as well as to develop a compound index for assessing phosphate overload with high validity and reliability.
Investigators will address the following specific aims: 1). To explore novel pathways of phosphate metabolism and assess the influence of CKD status on these metabolic pathways. 2). To identify novel biomarkers for phosphate overload that reflect changes in dietary phosphorus intake. 3). To develop a compound phosphate overload index that measures dietary phosphorus intake with high validity and reliability.
This study will provide novel insights into phosphate metabolism and the assessment of phosphate overload in CKD patients. This investigation aims to provide preliminary data to further studies for the development of reliable biomarkers in CKD patients, which could contribute significantly to early interventions and improve health outcomes.
Eligibility criteria
Qualifiers
Men or women aged 18 years or older, of any race/ethnicity
Women must either be post-menopausal or have no monthly menstrual cycle
Estimated total daily energy expenditure (TDEE) of 1700 - 2700 calories
eGFR >15 ml/min/1.73m2 - < 60 ml/min/1.73m2 for the CKD group (CKD Stage 3 or Stage 4)
Disqualifiers
Pregnant, currently breastfeeding, or <3 months postpartum
Current dialysis or kidney transplant patient
Current use of insulin or chemotherapy drugs
Smokes cigarettes or uses e-cigarettes (vapes)
Trial design
Treatments tested in this trial
- Dietary Phosphorus Intake
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov