Physiological Study of High PEEP in Noninvasive Ventilation
ConditionRespiratory Failure With Hypoxia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorChongqing Medical University
About this trial
To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.
Eligibility criteria
Qualifiers
Age ≥ 18 years
PaCO₂ ≤ 50 mmHg
PaO₂/FiO₂ ≤ 300 mmHg
Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) -
Disqualifiers
Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included)
Pneumothorax
Patients who refuse to participate in this trial -
Trial design
Treatments tested in this trial
- high PEEP
Treatment groups
50 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov