Pilot Study of the Human Metagenome in Metabolic Diseases
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21-99
SponsorSengkang General Hospital
About this trial
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia.
Recruited participants will have their fecal, salivary, urine, serum, and in certain instances, mucosal samples taken, for metagenomic sequencing and metabolite testing.
We hope to uncover various differences and signatures in the metagenome and metabolome in various diseased states, with potential future therapeutic applications in personalised medicine.
Eligibility criteria
Qualifiers
Obese (BMI>27.5kg/m2)
Sarcopenic patients, defined as 1) low handgrip strength (<26 for males; <18kg for females), AND/OR low gait speed (<0.8m/s) AND low muscle mass (<7.0kg/m2 for males; <5.7kg/m2 for females)
Disqualifiers
No informed consent
Presence of intestinal stoma, hence inability to collect fecal samples
Trial design
Treatments tested in this trial
- No specific intervention
Treatment groups
600 Participants
are divided into 3 treatment groupsSponsors and collaborators
Sengkang General Hospital
Lead sponsor
Singapore General Hospital
Collaborator
Nanyang Technological University
Collaborator
Duke-NUS Graduate Medical School
Collaborator
Source ClinicalTrials.gov