Endometriosis is a systemic, steroid-dependent, inflammatory disease characterized by the growth of endometrial-like tissue outside the uterus, affecting approximately 10 % of women of childbearing age. The etiology and pathophysiology of endometriosis is not completely understood to support effective treatment and prevention strategies. Despite the steroid dependency, little is known concerning the underlying metabolism of estrogen and other tightly related steroids. Moreover, shortening the long diagnostic delays is a major priority in endometriosis research.
Women aged 18 to 45
Free, informed and written consent from the patient to participate in the study
Good understanding of the French language
Patient affiliated to or benefiting from a social security or similar scheme
Intercurrent diagnosis of pregnancy.
Presence of other hormone-dependent pathologies (e.g. breast cancer, PCOS).
Acute infection.
The STERONLINE study population will be made up of women aged between 18 years and 45 years * 45 patients with endometrioma * 45 patients without endometrioma
Case-control
Prospective
Blood test
Other interventionA blood test (2 x 5 ml dry tubes) will be taken to analyze steroid profiles
urine sample
Other interventiona 20 ml urine sample will be taken to analyze steroid profiles
vaginal sample
Other interventionto characterize the microbiota.
Identify steroid profiles associated with endometriosis
Statistical associations between steroids and the presence of endometriosis.
Identify biomarkers of environmental chemical exposure associated with endometriosis and steroid profiles.
Statistical difference between environmental chemical and steroid exposure profiles between subgroups of the study populations.
Identify the role of vaginal microbiota dysbiosis on hormonal alteration in endometriosis
Presence of a specific bacterial community in the vaginal microbiota
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