An observational, cross-sectional, longitudinal, microdosing Position Emission Tomography (PET) imaging study to investigate platelet derived growth factor receptor beta (PDGFRß) expression in the heart of patients with high or low risk of heart failure after a ST-Elevation Myocardial Infarction (STEMI) after a percutaneous coronary intervention (PCI) with a stent procedure, as well as in patients with heart failure with preserved ejection fraction (HFpEF) and healthy individuals.
Willing and able to give written informed consent for participation in the trial and able to comply with all trial procedures and requirements.
Male or female participant aged 40 to 70 years, inclusive, at the screening visit.
Women of childbearing potential must practice abstinence from heterosexual intercourse or must agree to use a highly effective method of contraception.
NT-proBNP >500 pg/mL within 48 hrs after PCI
Any contraindication for MRI according to a standard checklist
Having worked as a metal worker or welder.
Contraindication for gadolinium-based contrast agents such as risk of nephrogenic systemic fibrosis (NSF) or allergy to gadolinium.
Kidney dysfunction measured as estimated Glomerular filtration rate (eGFR)<30 mL/min/1.73m2