Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age6-59
SponsorJohns Hopkins Bloomberg School of Public Health
About this trial
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
Eligibility criteria
Qualifiers
Age <5 years
Platelet count ≤75,000/uL
Hemoglobin >5 and ≤9 g/dL
P. falciparum parasitemia ≥500 parasites/uL
Disqualifiers
Residence in foster care or children otherwise under government supervision
Residence outside the hospital catchment area, or plan to leave the area
Presence of any other condition or abnormality which, in the opinion of the investigator, would compromise the safety of the participant or the quality of the data
Any contraindication to whole blood transfusion
Trial design
Treatments tested in this trial
- Whole blood transfusion
Treatment groups
132 Participants
are divided into 2 treatment groupsSponsors and collaborators
Johns Hopkins Bloomberg School of Public Health
Lead sponsor
Johns Hopkins University
Collaborator
Tropical Diseases Research Centre
Collaborator
University of California, San Francisco
Collaborator
University of Maryland
Collaborator
Source ClinicalTrials.gov