Platelet Function After Cardiac Surgery.

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorInsel Gruppe AG, University Hospital Bern

About this trial

Intraoperative cell salvage is commonly used in cardiac surgery to reduce the administration of allogeneic red blood cells and thus improve the outcome for the patient. When processing the salvaged blood, however, a large part of the patient's plasma is washed out. This is a disadvantage with regard to an optimal coagulation situation after cardiac surgery.

There are currently various cell saver systems on the market. According to the manufacturers, the plasma is returned to the patient in different quantities as part of the processing procedure. Thus, it can be assumed that in addition to red blood cells, platelets (part of plasma) are retransfused and contribute to an optimized coagulation. Unfortunately, there is a lack of studies in this regard in the cardiac surgery population.

The investigators aim to study the performance of two different cell saver devices regarding preservation of platelet number and function.

Eligibility criteria

Qualifiers

Age >18 years

Elective high risk cardiac surgery with cardiopulmonary bypass usage

Cardiopulmonary bypass time > 120 minutes

Written informed consent

Disqualifiers

Preoperative use of oral or intravenous anti-coagulants or antiplatelet agents (except aspirin)

Inability to understand and sign the informed consent form (e.g. language problems, dementia, mental disorders).

Trial design

Treatments tested in this trial

  • Autologous blood cell salvage with in-house device
  • Autologous cell salvage with i-Sep SAME device

Treatment groups

40 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Insel Gruppe AG, University Hospital Bern

Lead sponsor

University Hospital, Geneva

Collaborator

University of Zurich

Collaborator