Pollution Intervention to Impact Kids Asthma Study
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age8-17
SponsorUniversity of Pittsburgh
About this trial
The goal of this clinical trial is to learn if adding Air Quality Index (AQI) information to asthma action plans works to improve asthma outcomes in children. It will also learn about children with asthma who report being more sensitive to outdoor air pollution. The main questions it aims to answer are:
* Does adding either information about the EPA-AQI or commercial AQI improve asthma outcomes over time? * Are there changes in nasal gene expression in children with asthma who report they are more sensitive to outdoor air pollution?
Researchers will compare EPA-AQI and the commercial-AQI groups to a control group to either AQI works to improve asthma.
Participants will:
* Receive standardized outdoor air pollution education and an asthma action plan * Provide nose and blood specimens * Have visits every 4 weeks for 48 weeks, 10 will be conducted by telephone calls and 3 visits will be in person.
Eligibility criteria
Qualifiers
A healthcare provider diagnosis of persistent asthma (Steps 2-5 as defined by US guidelines) or intermittent asthma (Step 1) + at least one severe asthma exacerbation (defined by American Thoracic Society (ATS)/European Respiratory Society (ERS) criteria as requiring at least 3 days of systemic steroids or an Emergency Department/Urgent Care visit requiring systemic steroids) in the prior 12 months
Home access to a smartphone or internet
Primary residence in Allegheny County, PA
One participant per household
Disqualifiers
Diagnosis of other active chronic respiratory diseases (e.g., cystic fibrosis, bronchopulmonary dysplasia, etc.)
Neuromuscular disorder
Chronic disorder limiting independent ambulation (e.g., spastic quadriplegia, etc.)
Cyanotic heart disease
Trial design
Treatments tested in this trial
- EPA-AQI
- Commerical-AQI
- Education and plan
Treatment groups
351 Participants
are divided into 3 treatment groupsSponsors and collaborators
University of Pittsburgh
Lead sponsor
National Institute of Environmental Health Sciences (NIEHS)
Collaborator
Source ClinicalTrials.gov