About this trial
Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.
The search for outcome predictors is going to be subdivided into three main research areas:
1. outcome predictors in the emergency department (so called "early brain injury phase"). 2. outcome predictors in the neurocritical care unit (so called "delayed brain injury phase"). 3. Treatment strategies. Two other areas of research are identified: delayed cerebral ischemia (incidence, treatment, predictors, impact on outcome) and long term follow-up (recent evidences suggest that there may be a non-negligible proportion of poor grade subarachnoid hemorrhage patients who may benefit from substantial improvement at long-term (after 6-12 months of follow-up).
Eligibility criteria
Qualifiers
Patients admitted to the emergency department because of aneurysmal subarachnoid hemorrhage of poor grade (IV-V) according to the WFNS classification.
Disqualifiers
Patients younger than 18 years old.
Pregnant or breast-feeding patients.
Aneurysmal subarachnoid hemorrhage due to trauma or vascular malformations other than cerebral aneurysms.
Trial design
Treatments tested in this trial
- Standard management according to international/national guidelines
Treatment groups
Sponsors and collaborators
IRCCS San Raffaele
Lead sponsor
Azienda Ospedaliera Universitaria Integrata Verona
Collaborator
Azienda Ospedaliero-Universitaria di Parma
Collaborator
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Collaborator
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Collaborator
A.O. Ospedale Papa Giovanni XXIII
Collaborator
ASL Taranto
Collaborator
Ospedale V. Fazzi
Collaborator
IRCCS Istituto delle Scienze Neurologiche di Bologna
Collaborator
Azienda Ospedaliero Universitaria Maggiore della Carita
Collaborator