Poor Grade Aneurysmal Subarachnoid Hemorrhage Study Group

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorIRCCS San Raffaele

About this trial

Multicentric registry study in order to define outcome, predictors, treatment effects and their modifiers in poor grade aneurysmal subarachnoid haemorrhage patients.

The search for outcome predictors is going to be subdivided into three main research areas:

1. outcome predictors in the emergency department (so called "early brain injury phase"). 2. outcome predictors in the neurocritical care unit (so called "delayed brain injury phase"). 3. Treatment strategies. Two other areas of research are identified: delayed cerebral ischemia (incidence, treatment, predictors, impact on outcome) and long term follow-up (recent evidences suggest that there may be a non-negligible proportion of poor grade subarachnoid hemorrhage patients who may benefit from substantial improvement at long-term (after 6-12 months of follow-up).

Eligibility criteria

Qualifiers

Patients admitted to the emergency department because of aneurysmal subarachnoid hemorrhage of poor grade (IV-V) according to the WFNS classification.

Disqualifiers

Patients younger than 18 years old.

Pregnant or breast-feeding patients.

Aneurysmal subarachnoid hemorrhage due to trauma or vascular malformations other than cerebral aneurysms.

Trial design

Treatments tested in this trial

  • Standard management according to international/national guidelines

Treatment groups

800 Participants
are divided into 1 treatment group

Sponsors and collaborators

IRCCS San Raffaele

Lead sponsor

Azienda Ospedaliera Universitaria Integrata Verona

Collaborator

Azienda Ospedaliero-Universitaria di Parma

Collaborator

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Collaborator

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Collaborator

A.O. Ospedale Papa Giovanni XXIII

Collaborator

ASL Taranto

Collaborator

Ospedale V. Fazzi

Collaborator

IRCCS Istituto delle Scienze Neurologiche di Bologna

Collaborator

Azienda Ospedaliero Universitaria Maggiore della Carita

Collaborator