About this trial
Accurate and non-invasive methods for objectively identifying and monitoring head injuries (such as a concussion) are still an unmet need. It is known that pupil constriction in response to light stimuli can reflect changes in neural activity in the brain and is associated with sleep disturbances.
The investigators aim to examine the feasibility of using virtual reality goggles for monitoring traumatic brain injury by analyzing the pupillary response to multifocal chromatic stimuli. The VR device was programmed to present brief, low-intensity light stimuli (without glare), while the headset's camera records the pupil's reaction.
Eligibility criteria
Qualifiers
Male and female subjects
Clear ocular media a
Combat-related mild to moderate TBI
Have either elevated TBI-associated blood biomarkers (Abbott Allinity I, GFAP/ UCHL1) and/or initial trauma head CT positive for acute intracranial trauma
Disqualifiers
Neuropsychiatric diseases
Any other neurodegenerative diseases
History of stroke, epilepsy, head trauma, or head tumors
Ocular disease or ocular surgery within the last six months
Trial design
Treatments tested in this trial
- Virtual Reality pupillometry test
Treatment groups
Sponsors and collaborators
Sheba Medical Center
Lead sponsor
Reichman University
Collaborator