Portable VR-based Chromatic Pupilloperimeter for Diagnosis and Monitoring of Traumatic Brain Injury

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-67
SponsorSheba Medical Center

About this trial

Accurate and non-invasive methods for objectively identifying and monitoring head injuries (such as a concussion) are still an unmet need. It is known that pupil constriction in response to light stimuli can reflect changes in neural activity in the brain and is associated with sleep disturbances.

The investigators aim to examine the feasibility of using virtual reality goggles for monitoring traumatic brain injury by analyzing the pupillary response to multifocal chromatic stimuli. The VR device was programmed to present brief, low-intensity light stimuli (without glare), while the headset's camera records the pupil's reaction.

Eligibility criteria

Qualifiers

Male and female subjects

Clear ocular media a

Combat-related mild to moderate TBI

Have either elevated TBI-associated blood biomarkers (Abbott Allinity I, GFAP/ UCHL1) and/or initial trauma head CT positive for acute intracranial trauma

Disqualifiers

Neuropsychiatric diseases

Any other neurodegenerative diseases

History of stroke, epilepsy, head trauma, or head tumors

Ocular disease or ocular surgery within the last six months

Trial design

Treatments tested in this trial

  • Virtual Reality pupillometry test

Treatment groups

150 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Sheba Medical Center

Lead sponsor

Reichman University

Collaborator