Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorAristotle University Of Thessaloniki
About this trial
This randomized study tests whether a new multicomponent Positive Psychology program can improve cognition and wellbeing in older adults at the earliest stages of dementia-related decline.
About 128 participants with Subjective Cognitive Decline or Mild Cognitive Impairment will be enrolled. Half will be randomized to the Positive Psychology program and half to Treatment As Usual (TAU).
The program consists of weekly, small-group online sessions for \~24 weeks plus brief home practices. All participants (both arms) will complete questionnaires and cognitive tests at baseline, during treatment, post-treatment, and 9-month follow-up.
Primary question: Do participants receiving the Positive Psychology program show better cognitive and brain-function outcomes than TAU at post-treatment and at 9 months? Secondary question: Are effects larger for SCD than MCI? No medicines are used and risks are minimal. If effective, this scalable, low-cost, non-pharmacological approach could complement usual care for people in very early cognitive decline.
Eligibility criteria
Qualifiers
None
Disqualifiers
Diagnosis of dementia (major neurocognitive disorder) or other major neurocognitive disorder that is moderate or severe.
Major psychiatric disorder currently unstable or untreated (e.g., major depression with psychotic features, bipolar disorder, schizophrenia).
Neurological conditions that affect cognition.
Uncorrected hearing or vision problems that prevent participation in assessments or online sessions.
Trial design
Treatments tested in this trial
- Positive Psychology Intervention
- Treatment as usual (TAU)
Treatment groups
128 Participants
are divided into 2 treatment groupsSponsors and collaborators
Aristotle University Of Thessaloniki
Lead sponsor
Alzheimer Hellas
Collaborator
Source ClinicalTrials.gov