Postoperative Hypofractionated Radiation in Cervical and Endometrial Tumours: Phase II Study
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-80
SponsorTata Memorial Centre
About this trial
The primary aim of the trial is to investigate the late effects of hypofractionated external radiation (39 Gy in 13 fractions) in patients requiring post-operative radiation for early-stage cervical and endometrial cancers.
Eligibility criteria
Qualifiers
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
Histologically confirmed diagnosis of cervical cancer post hysterectomy with intermediate or high-risk features, requiring adjuvant EBRT ± concurrent chemotherapy OR histologically confirmed diagnosis of endometrial cancer post hysterectomy requiring adjuvant (chemo)radiotherapy to pelvis with/without vaginal brachytherapy.
Disqualifiers
Patients with macroscopic residual disease (R+ resection) postoperatively
Patients requiring extended field radiotherapy (patients with involved para-aortic lymph nodes in cervical or endometrial cancer)
Patients treated with chemotherapy for any prior malignancy at any time
Patients treated with pelvic radiation previously
Trial design
Treatments tested in this trial
- Hypofractionated Image guided External Beam Radiation Therapy (EBRT)
- Cisplatin
- Vaginal brachytherapy
Treatment groups
90 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov