Potassium-Competitive Acid Blocker Versus Proton Pump Inhibitor as A Part of Bismuth Based Quadruple Therapy for Treatment of Helicobacter Pylori Infection

ConditionsPotassium-Competitive Acid Blocker Proton Pump Inhibitor Bismuth Based Quadruple Therapy Treatment Helicobacter Pylori Infection

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorTanta University

About this trial

This study aims to compare the eradication rate, safety, and patient adherence between potassium-competitive acid blockers (P-CABs) and proton pump inhibitor-based bismuth quadruple therapy in patients with Helicobacter pylori infection.

Eligibility criteria

Qualifiers

Adults aged ≥18 years.

Both sexes.

Confirmed Helicobacter pylori infection by stool antigen (3rd-gen ELISA) or urea breath test (UBT).

No prior eradication therapy.

Disqualifiers

Prior Helicobacter pylori treatment.

Use of antibiotics, proton pump inhibitor, or bismuth in the prior 4 weeks.

Gastric surgery history.

Major organ failure.

Trial design

Treatments tested in this trial

Potassium-Competitive Acid Blocker
Proton Pump Inhibitor

Treatment groups

320 Participants

are divided into 2 treatment groups

Sponsors and collaborators

Tanta University

Lead sponsor

Source ClinicalTrials.gov