To gain a comprehensive understanding of the biomechanical behaviour of human heart to explore the concept of myocardial fatigue in response to a temporal range of preload, afterload and drug-induced inotropy using in-vitro contractile assays.
All adult patients between 18 to 85-years old undergoing open-heart surgery who can undergo the consent process for the study
Healthy donor hearts that are deemed non-transplantable and consent received from a legal representative
Patients who do not have the mental capacity to undergo the consent process
For the safety of researchers, patients with evidence of ongoing blood-borne infections such as HIV, or a recent positive test for COVID-19 (within 10 days of last PCR test).
University Hospitals Coventry and Warwickshire NHS Trust
Lead sponsor
Coventry University
Collaborator