Prealbumin and IGF-1 Levels in Pediatric Chronic Cholestasis With Severe Malnutrition After Nutrition Therapy

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeUp to 5
SponsorIndonesia University

About this trial

The goal of this clinical trial is to learn if a high-energy liquid diet improves the nutritional status of children with chronic cholestasis (a liver condition that blocks bile flow). Researchers want to see if this diet helps children who are malnourished.

The main questions the study aims to answer are:

* Does the liquid diet raise the level of prealbumin (a marker of nutrition) in the blood? * Does the liquid diet raise the level of Insulin-like Growth Factor-1 (IGF-1) (a hormone that helps growth) in the blood?

Participants will:

* Consume a high-energy liquid diet for 14 days. * Give blood samples at the start and at the end of the 2-week study. * Keep a daily record of what they eat and drink in a food diary. Researchers will compare the blood test results from the start and the end of the study to see if the liquid diet works to improve the children's prealbumin and IGF-1 levels. This study is important to help children with liver problems grow better and stay healthy.

Eligibility criteria

Qualifiers

Children under 5 years old

Diagnosed with chronic cholestasis and severe malnutrition

Parental/guardian informed consent

Willingness to use a nasogastric tube (NGT) if indicated

Disqualifiers

Comorbidities (heart failure, chronic kidney disease, HIV)

Severe acute infections (acute gastroenteritis, dengue fever, pneumonia)

Post-liver transplant

Post-Kasai portoenterostomy (jaundice-free)

Trial design

Treatments tested in this trial

  • Nutrition Therapy

Treatment groups

15 Participants
are divided into 1 treatment group

Sponsors and collaborators