Precision-Medicine Diagnostic Support in Hospitalized Veterans With Acute Kidney Injury

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorVA Office of Research and Development

About this trial

Acute kidney injury (AKI) affects up to 20% of hospitalized Veterans and is strongly associated with morbidity and death. AKI is a diverse condition and timely and accurate diagnosis of the type of AKI is critical to begin appropriate therapies, especially those causes that require specific treatments beyond general supportive care. Yet, there are still significant gaps in the initial evaluation of AKI among hospitalized patients. Clinical decision support systems (CDSS) have shown promise to address these barriers, but most consist of simple alerting schemes and general care recommendations provided at a single point in time. The goal of this proposal is to develop and test the feasibility and usability of a rule-based and Artificial Intelligence-assisted precision CDSS tool (PRECISE-AKI) that can provide cognitive support to improve timely initial diagnostic evaluation of AKI.

Eligibility criteria

Qualifiers

Eligible providers will be those that have at least 4 weeks of inpatient ward team or consultation team activity during a 12-month period.

Case inclusion criteria will consist of hospitalizations that meet criteria for Kidney Disease Improving Global Outcomes Stage 2 injury or persistent Stage 1 injury seen by eligible providers.

Disqualifiers

Ineligible providers will be those that have < 4 weeks of inpatient ward team of consultative team activity during a 12 month period.

Hospitalizations with non-persistent (<48 hours) stage 1 injury or less.

Trial design

Treatments tested in this trial

  • PRECISE-AKI Clinical Decision Support Tool

Treatment groups

60 Participants
are divided into 2 treatment groups

Sponsors and collaborators

VA Office of Research and Development

Lead sponsor

VA Tennessee Valley Health Care System

Collaborator

Vanderbilt University Medical Center

Collaborator