Precision OSA Therapy Based on Phenotypes and Endotypes
ConditionObstructive Sleep Apnea
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorNanjing Medical University
About this trial
Analyzing the phenotypic and endotypic characteristics of Sleep Apnea, along with DISE obstruction situations, is crucial for precise diagnosis and treatment. In this study, we aim to construct and apply a multidimensional predictive model based on four aspects: basic physiological characteristics of OSA, clinical phenotypes, mechanistic endotypes, and DISE obstruction levels. The study will begin by categorizing the clinical phenotypes; subsequently, it will quantify endotypic indicators based on PSG signal information and construct the PALM scale for Chinese individuals. Following this, a comprehensive clinical profile and a treatment efficacy prediction model for OSA patients will be built based on the results from the aforementioned multidimensional data.
Eligibility criteria
Qualifiers
Patients aged between 18 and 80 years.
Diagnosed with Obstructive Sleep Apnea (OSA)(apnea-hypopnea index≥5/h).
First-time diagnosis, with no previous surgical interventions or CPAP treatment for OSA.
Ability and willingness to provide informed consent for participation in the study.
Disqualifiers
History of severe stroke or cerebral hemorrhage, or presence of neurological or psychiatric conditions that could affect study results.
Presence of active malignancies or other severe underlying diseases, such as severe liver or kidney dysfunction. Diagnosed with diabetes or other significant vascular diseases.
Presence of severe chronic obstructive pulmonary disease (COPD), severe asthma, severe pulmonary hypertension, or heart failure caused by any condition.
Pregnancy or having other conditions that make participation in this study unsuitable.
Trial design
Treatments tested in this trial
- Clinical and Endotypic Assessmen
Treatment groups
200 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov