PREconception Folic Acid Clinical Efficacy (PREFACE) Trial
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age19-42
SponsorUniversity of British Columbia
About this trial
A study to help understand what forms of folic acid are most effective to increase folate status during pregnancy for the best protection against neural tube defects
Eligibility criteria
Qualifiers
Currently trying to become pregnant;
Aged 19-42 years;
Low risk for an NTD-affected pregnancy
Disqualifiers
Trying to conceive for ≥6 months (as ~90% of pregnancies occur after 6 months of trying);
Diagnosed ovulatory disorders (polycystic ovary syndrome, endometriosis, or menstrual irregularity);
More than 2 miscarriages in the past year;
Undergoing fertility assistance (including current IVF or intrauterine insemination);
Trial design
Treatments tested in this trial
- Folic Acid
- 5-MTHF (5-methyltetrahydrofolate)
Treatment groups
272 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
University of British Columbia
Lead sponsor
University of Saskatchewan
Collaborator
Source ClinicalTrials.gov